microRNA-199a-3p inhibits hepatic apoptosis and hepatocarcinogenesis by targeting PDCD4
نویسندگان
چکیده
منابع مشابه
MicroRNA-205 inhibits renal cells apoptosis via targeting CMTM4
Objective(s):MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression. They have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (CKD). In the present study, we elucidated the role of microR...
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Programmed cell death 4 (PDCD4) is a novel tumor suppressor gene and a promising target for anticancer therapies. PDCD4 is frequently downregulated in various human cancers; however, the molecular mechanism accounting for the loss expression of PDCD4 in cancers is not fully understood. In this study, we identified specific targeting sites for miR-208a-3p in the 3'-untranslated region (3'-UTR) o...
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ژورنال
عنوان ژورنال: Oncogenesis
سال: 2020
ISSN: 2157-9024
DOI: 10.1038/s41389-020-00282-y